Ontology highlight
ABSTRACT:
SUBMITTER: Burke AR
PROVIDER: S-EPMC3875221 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Burke Andrew R AR Singh Ravi N RN Carroll David L DL Torti Frank M FM Torti Suzy V SV
Journal of molecular biomarkers & diagnosis 20120701
Emerging evidence suggests that multiple tumor types are sustained by a small population of transformed stem-like cells that have the ability to both self-renew and give rise to non-tumorigenic daughter cells that constitute the bulk of a tumor. These cells, which generally constitute a minority of the overall cancer cell population, are highly resistant to conventional therapies and persist following treatment, leading to disease relapse and the formation of distant metastases. Therapies that d ...[more]