Characterization of the yehUT two-component regulatory system of Salmonella enterica Serovar Typhi and Typhimurium.
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ABSTRACT:
SUBMITTER: Wong VK
PROVIDER: S-EPMC3875573 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
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Characterization of the yehUT two-component regulatory system of Salmonella enterica Serovar Typhi and Typhimurium.
Wong Vanessa K VK Pickard Derek J DJ Barquist Lars L Sivaraman Karthikeyan K Page Andrew J AJ Hart Peter J PJ Arends Mark J MJ Holt Kathryn E KE Kane Leanne L Mottram Lynda F LF Ellison Louise L Bautista Ruben R McGee Chris J CJ Kay Sally J SJ Wileman Thomas M TM Kenney Linda J LJ MacLennan Calman A CA Kingsley Robert A RA Dougan Gordon G
PloS one 20131230 12
Proteins exhibiting hyper-variable sequences within a bacterial pathogen may be associated with host adaptation. Several lineages of the monophyletic pathogen Salmonella enterica serovar Typhi (S. Typhi) have accumulated non-synonymous mutations in the putative two-component regulatory system yehUT. Consequently we evaluated the function of yehUT in S. Typhi BRD948 and S. Typhimurium ST4/74. Transcriptome analysis identified the cstA gene, encoding a carbon starvation protein as the predominantl ...[more]
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