Unbiased transcriptome signature of in vivo cell proliferation reveals pro- and antiproliferative gene networks.
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ABSTRACT:
SUBMITTER: Cohen M
PROVIDER: S-EPMC3875674 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Publications
Unbiased transcriptome signature of in vivo cell proliferation reveals pro- and antiproliferative gene networks.
Cohen Meital M Vecsler Manuela M Liberzon Arthur A Noach Meirav M Zlotorynski Eitan E Tzur Amit A
Cell cycle (Georgetown, Tex.) 20130813 18
Different types of mature B-cell lymphocytes are overall highly similar. Nevertheless, some B cells proliferate intensively, while others rarely do. Here, we demonstrate that a simple binary classification of gene expression in proliferating vs. resting B cells can identify, with remarkable selectivity, global in vivo regulators of the mammalian cell cycle, many of which are also post-translationally regulated by the APC/C E3 ligase. Consequently, we discover a novel regulatory network between t ...[more]
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