Ontology highlight
ABSTRACT:
SUBMITTER: Chu S
PROVIDER: S-EPMC3876588 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Chu Sophie S Zhang Hanjie H Maher Christina C McDonald Jacob D JD Zhang Xiang X Ho Shuk-Mei SM Yan Beizhan B Chillrud Steven S Perera Frederica F Factor Phillip P Miller Rachel L RL
Journal of toxicology 20131212
Despite data associating exposure to traffic-related polycyclic aromatic hydrocarbons (PAH) in asthma, mechanistic support has been limited. We hypothesized that both prenatal and early postnatal exposure to PAH would increase airway hyperreactivity (AHR) and that the resulting AHR may be insensitive to treatment with a β 2AR agonist drug, procaterol. Further, we hypothesized that these exposures would be associated with altered β 2AR gene expression and DNA methylation in mouse lungs. Mice were ...[more]