Ontology highlight
ABSTRACT:
SUBMITTER: Mori N
PROVIDER: S-EPMC387669 | biostudies-literature | 2004 May
REPOSITORIES: biostudies-literature
Mori Naoki N Matsuda Takehiro T Tadano Masayuki M Kinjo Takao T Yamada Yasuaki Y Tsukasaki Kunihiro K Ikeda Shuichi S Yamasaki Yoshihiro Y Tanaka Yuetsu Y Ohta Takao T Iwamasa Teruo T Tomonaga Masao M Yamamoto Naoki N
Journal of virology 20040501 9
Inhibition of histone deacetylase (HDAC) activity induces growth arrest, differentiation, and, in certain cell types, apoptosis. FR901228, FK228, or depsipeptide, is an HDAC inhibitor effective in T-cell lymphomas. Adult T-cell leukemia (ATL) is caused by human T-cell leukemia virus type 1 (HTLV-1) and remains incurable. We examined whether FR901228 is effective for treatment of ATL by assessing its ability to induce apoptosis of HTLV-1-infected T-cell lines and primary leukemic cells from ATL p ...[more]