Optogenetic stimulation of lateral orbitofronto-striatal pathway suppresses compulsive behaviors.
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ABSTRACT:
SUBMITTER: Burguiere E
PROVIDER: S-EPMC3876800 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Publications
Optogenetic stimulation of lateral orbitofronto-striatal pathway suppresses compulsive behaviors.
Burguière Eric E Monteiro Patrícia P Feng Guoping G Graybiel Ann M AM
Science (New York, N.Y.) 20130601 6137
Dysfunctions in frontostriatal brain circuits have been implicated in neuropsychiatric disorders, including those characterized by the presence of repetitive behaviors. We developed an optogenetic approach to block repetitive, compulsive behavior in a mouse model in which deletion of the synaptic scaffolding gene, Sapap3, results in excessive grooming. With a delay-conditioning task, we identified in the mutants a selective deficit in behavioral response inhibition and found this to be associate ...[more]
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