Centromere tethering confines chromosome domains.
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ABSTRACT:
SUBMITTER: Verdaasdonk JS
PROVIDER: S-EPMC3877211 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Publications
Centromere tethering confines chromosome domains.
Verdaasdonk Jolien Suzanne JS Vasquez Paula Andrea PA Barry Raymond Mario RM Barry Timothy T Goodwin Scott S Forest M Gregory MG Bloom Kerry K
Molecular cell 20131121 6
The organization of chromosomes into territories plays an important role in a wide range of cellular processes, including gene expression, transcription, and DNA repair. Current understanding has largely excluded the spatiotemporal dynamic fluctuations of the chromatin polymer. We combine in vivo chromatin motion analysis with mathematical modeling to elucidate the physical properties that underlie the formation and fluctuations of territories. Chromosome motion varies in predicted ways along th ...[more]
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