Ontology highlight
ABSTRACT:
SUBMITTER: Zhao B
PROVIDER: S-EPMC3877362 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Zhao Bing B Zhang Meng M Han Xue X Zhang Xia-Yan XY Xing Qiong Q Dong Xu X Shi Qiao-Juan QJ Huang Peng P Lu Yun-Bi YB Wei Er-Qing EQ Xia Qiang Q Zhang Wei-Ping WP Tang Chun C
PloS one 20131231 12
Intracellular nicotinamide phosphoribosyltransferase (iNAMPT) in neuron has been known as a protective factor against cerebral ischemia through its enzymatic activity, but the role of central extracellular NAMPT (eNAMPT) is not clear. Here we show that eNAMPT protein level was elevated in the ischemic rat brain after middle-cerebral-artery occlusion (MCAO) and reperfusion, which can be traced to at least in part from blood circulation. Administration of recombinant NAMPT protein exacerbated MCAO ...[more]