Ontology highlight
ABSTRACT:
SUBMITTER: Riley JS
PROVIDER: S-EPMC3877552 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Riley J S JS Hutchinson R R McArt D G DG Crawford N N Holohan C C Paul I I Van Schaeybroeck S S Salto-Tellez M M Johnston P G PG Fennell D A DA Gately K K O'Byrne K K Cummins R R Kay E E Hamilton P P Stasik I I Longley D B DB
Cell death & disease 20131205
Non-small cell lung carcinoma remains by far the leading cause of cancer-related deaths worldwide. Overexpression of FLIP, which blocks the extrinsic apoptotic pathway by inhibiting caspase-8 activation, has been identified in various cancers. We investigated FLIP and procaspase-8 expression in NSCLC and the effect of HDAC inhibitors on FLIP expression, activation of caspase-8 and drug resistance in NSCLC and normal lung cell line models. Immunohistochemical analysis of cytoplasmic and nuclear F ...[more]