Ontology highlight
ABSTRACT:
SUBMITTER: Vinayagam A
PROVIDER: S-EPMC3877743 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Vinayagam Arunachalam A Zirin Jonathan J Roesel Charles C Hu Yanhui Y Yilmazel Bahar B Samsonova Anastasia A AA Neumüller Ralph A RA Mohr Stephanie E SE Perrimon Norbert N
Nature methods 20131117 1
A major objective of systems biology is to organize molecular interactions as networks and to characterize information flow within networks. We describe a computational framework to integrate protein-protein interaction (PPI) networks and genetic screens to predict the 'signs' of interactions (i.e., activation-inhibition relationships). We constructed a Drosophila melanogaster signed PPI network consisting of 6,125 signed PPIs connecting 3,352 proteins that can be used to identify positive and n ...[more]