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Clear castable polyurethane elastomer for fabrication of microfluidic devices.

ABSTRACT: Polydimethylsiloxane (PDMS) has numerous desirable properties for fabricating microfluidic devices, including optical transparency, flexibility, biocompatibility, and fabrication by casting; however, partitioning of small hydrophobic molecules into the bulk of PDMS hinders industrial acceptance of PDMS microfluidic devices for chemical processing and drug development applications. Here we describe an attractive alternative material that is similar to PDMS in terms of optical transparency, flexibility and castability, but that is also resistant to absorption of small hydrophobic molecules.

SUBMITTER: Domansky K

PROVIDER: S-EPMC3877836 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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Clear castable polyurethane elastomer for fabrication of microfluidic devices.

Domansky Karel K Leslie Daniel C DC McKinney James J Fraser Jacob P JP Sliz Josiah D JD Hamkins-Indik Tiama T Hamilton Geraldine A GA Bahinski Anthony A Ingber Donald E DE

Lab on a chip 20131001 19

Polydimethylsiloxane (PDMS) has numerous desirable properties for fabricating microfluidic devices, including optical transparency, flexibility, biocompatibility, and fabrication by casting; however, partitioning of small hydrophobic molecules into the bulk of PDMS hinders industrial acceptance of PDMS microfluidic devices for chemical processing and drug development applications. Here we describe an attractive alternative material that is similar to PDMS in terms of optical transparency, flexib ...[more]

PMID: 23954953

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