Activation of the nuclear factor E2-related factor 2 pathway by novel natural products halomadurones A-D and a synthetic analogue.
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ABSTRACT:
SUBMITTER: Wyche TP
PROVIDER: S-EPMC3877905 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
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Activation of the nuclear factor E2-related factor 2 pathway by novel natural products halomadurones A-D and a synthetic analogue.
Wyche Thomas P TP Standiford Miranda M Hou Yanpeng Y Braun Doug D Johnson Delinda A DA Johnson Jeffrey A JA Bugni Tim S TS
Marine drugs 20131216 12
Two novel chlorinated pyrones, halomadurones A and B, and two novel brominated analogues, halomadurones C and D, were isolated from a marine Actinomadura sp. cultivated from the ascidian Ecteinascidia turbinata. Additionally, a non-halogenated analogue, 2-methyl-6-((E)-3-methyl-1,3-hexadiene)-γ-pyrone, was synthesized to understand the role of the halogens for activity. Halomadurones C and D demonstrated potent nuclear factor E2-related factor antioxidant response element (Nrf2-ARE) activation, ...[more]
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