Ontology highlight
ABSTRACT:
SUBMITTER: Pollara J
PROVIDER: S-EPMC3878369 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Pollara Justin J Bonsignori Mattia M Moody M Anthony MA Pazgier Marzena M Haynes Barton F BF Ferrari Guido G
Current HIV research 20130701 5
Antibody dependent cellular cytotoxicity [ADCC] has been suggested to play an important role in control of Human Immunodeficiency Virus-1 [HIV-1] viral load and protection from infection. ADCC antibody responses have been mapped to multiple linear and conformational epitopes within the HIV-1 envelope glycoproteins gp120 and gp41. Many epitopes targeted by antibodies that mediate ADCC overlap with those recognized by antibodies capable of virus neutralization. In addition, recent studies conducte ...[more]