Integrative genomics with mediation analysis in a survival context.
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ABSTRACT:
SUBMITTER: Nemes S
PROVIDER: S-EPMC3878392 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Integrative genomics with mediation analysis in a survival context.
Nemes Szilárd S Parris Toshima Z TZ Danielsson Anna A Einbeigi Zakaria Z Steineck Gunnar G Jonasson Junmei Miao JM Helou Khalil K
Computational and mathematical methods in medicine 20131218
DNA copy number aberrations (DCNA) and subsequent altered gene expression profiles may have a major impact on tumor initiation, on development, and eventually on recurrence and cancer-specific mortality. However, most methods employed in integrative genomic analysis of the two biological levels, DNA and RNA, do not consider survival time. In the present note, we propose the adoption of a survival analysis-based framework for the integrative analysis of DCNA and mRNA levels to reveal their implic ...[more]
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