Ontology highlight
ABSTRACT:
SUBMITTER: Legorreta-Haquet MV
PROVIDER: S-EPMC3878598 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Legorreta-Haquet Maria Victoria MV Flores-Fernández Rocio R Blanco-Favela Francisco F Fuentes-Pananá Ezequiel M EM Chávez-Sánchez Luis L Hernández-González Rafael R Tesoro-Cruz Emiliano E Arriaga-Pizano Lourdes L Chávez-Rueda Adriana Karina AK
Clinical & developmental immunology 20131210
Prolactin (PRL) plays an important role in modulating the immune response. In B cells, PRL enhances antibody production, including antibodies with self-specificity. In this study, our aims were to determine the level of PRL receptor expression during bone-marrow B-cell development and to assess whether the presence of high PRL serum concentrations influences absolute numbers of developing populations and disease outcome in lupus-prone murine models. We observed that the PRL-receptor is expressed ...[more]