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Presence of pili on the surface of Francisella tularensis.


ABSTRACT: Francisella tularensis is a highly infectious gram-negative bacterium with potential for use as a bioweapon. Analysis of the F. tularensis live vaccine strain (LVS) ultrastructure by electron microscopy revealed the presence of long, thin fibers, similar in appearance to type 4 pili. The highly virulent F. tularensis Schu S4 strain was found to contain type 4 pilus genes, and we confirmed that these genes are present and expressed in the LVS.

SUBMITTER: Gil H 

PROVIDER: S-EPMC387894 | biostudies-literature | 2004 May

REPOSITORIES: biostudies-literature

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Presence of pili on the surface of Francisella tularensis.

Gil Horacio H   Benach Jorge L JL   Thanassi David G DG  

Infection and immunity 20040501 5


Francisella tularensis is a highly infectious gram-negative bacterium with potential for use as a bioweapon. Analysis of the F. tularensis live vaccine strain (LVS) ultrastructure by electron microscopy revealed the presence of long, thin fibers, similar in appearance to type 4 pili. The highly virulent F. tularensis Schu S4 strain was found to contain type 4 pilus genes, and we confirmed that these genes are present and expressed in the LVS. ...[more]

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