Effects of lifestyle and single nucleotide polymorphisms on breast cancer risk: a case-control study in Japanese women.

ABSTRACT:

Background

Lifestyle factors, including food and nutrition, physical activity, body composition and reproductive factors, and single nucleotide polymorphisms (SNPs) are associated with breast cancer risk, but few studies of these factors have been performed in the Japanese population. Thus, the goals of this study were to validate the association between reported SNPs and breast cancer risk in the Japanese population and to evaluate the effects of SNP genotypes and lifestyle factors on breast cancer risk.

Methods

A case-control study in 472 patients and 464 controls was conducted from December 2010 to November 2011. Lifestyle was examined using a self-administered questionnaire. We analyzed 16 breast cancer-associated SNPs based on previous GWAS or candidate-gene association

SUBMITTER: Mizoo T 

PROVIDER: S-EPMC3879029 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature