Ontology highlight
ABSTRACT:
SUBMITTER: Lewis IA
PROVIDER: S-EPMC3879234 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Lewis Ian A IA Wacker Mark M Olszewski Kellen L KL Cobbold Simon A SA Baska Katelynn S KS Tan Asako A Ferdig Michael T MT Llinás Manuel M
PLoS genetics 20140102 1
Drug resistant strains of the malaria parasite, Plasmodium falciparum, have rendered chloroquine ineffective throughout much of the world. In parts of Africa and Asia, the coordinated shift from chloroquine to other drugs has resulted in the near disappearance of chloroquine-resistant (CQR) parasites from the population. Currently, there is no molecular explanation for this phenomenon. Herein, we employ metabolic quantitative trait locus mapping (mQTL) to analyze progeny from a genetic cross bet ...[more]