Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC3879812 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Wang Yuying Y Pan Luyuan L Moens Cecilia B CB Appel Bruce B
Development (Cambridge, England) 20131204 2
Brain pericytes are important regulators of brain vascular integrity, permeability and blood flow. Deficiencies of brain pericytes are associated with neonatal intracranial hemorrhage in human fetuses, as well as stroke and neurodegeneration in adults. Despite the important functions of brain pericytes, the mechanisms underlying their development are not well understood and little is known about how pericyte density is regulated across the brain. The Notch signaling pathway has been implicated i ...[more]