Ontology highlight
ABSTRACT:
SUBMITTER: Byun HS
PROVIDER: S-EPMC3880124 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Byun Hoe-Sup HS Pyne Susan S Macritchie Neil N Pyne Nigel J NJ Bittman Robert R
MedChemComm 20130101 10
Sphingosine 1-phosphate (S1P) is involved in hyper-proliferative diseases such as cancer and pulmonary arterial hypertension. We have synthesized inhibitors that are selective for the two isoforms of sphingosine kinase (SK1 and SK2) that catalyze the synthesis of S1P. A thiourea adduct of sphinganine (<b>F02</b>) is selective for SK2 whereas the 1-deoxysphinganines <b>55-21</b> and <b>77-7</b> are selective for SK1. (2<i>S</i>,3<i>R</i>)-1-Deoxysphinganine (<b>55-21</b>) induced the proteasomal ...[more]