Ontology highlight
ABSTRACT:
SUBMITTER: Sliwoski G
PROVIDER: S-EPMC3880464 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Sliwoski Gregory G Kothiwale Sandeepkumar S Meiler Jens J Lowe Edward W EW
Pharmacological reviews 20131231 1
Computer-aided drug discovery/design methods have played a major role in the development of therapeutically important small molecules for over three decades. These methods are broadly classified as either structure-based or ligand-based methods. Structure-based methods are in principle analogous to high-throughput screening in that both target and ligand structure information is imperative. Structure-based approaches include ligand docking, pharmacophore, and ligand design methods. The article d ...[more]