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Galectin-9 plasma levels reflect adverse hematological and immunological features in acute dengue virus infection.

ABSTRACT: Dengue virus (DENV) infection remains a major public health burden worldwide. Soluble mediators may play a critical role in the pathogenesis of acute DENV infection. Galectin-9 (Gal-9) is a soluble ?-galactoside-binding lectin, with multiple immunoregulatory and inflammatory properties.To investigate plasma Gal-9 levels as a biomarker for DENV infection.We enrolled 65 DENV infected patients during the 2010 epidemic in the Philippines and measured their plasma Gal-9 and cytokine/chemokine levels, DENV genotypes, and copy number during the critical and recovery phases of illness.During the critical phase, Gal-9 levels were significantly higher in DENV infected patients compared to healthy or those with non-dengue febrile illness. The highest Gal-9 levels were observed in dengue hemorrhagic fever (DHF) patients (DHF: 2464 pg/ml; dengue fever patients (DF): 1407 pg/ml; non-dengue febrile illness: 616 pg/ml; healthy: 196 pg/ml). In the recovery phase, Gal-9 levels significantly declined from peak levels in DF and DHF patients. Gal-9 levels tracked viral load, and were associated with multiple cytokines and chemokines (IL-1?, IL-8, IP-10, and VEGF), including monocyte frequencies and hematologic variables of coagulation. Further discriminant analyses showed that eotaxin, Gal-9, IFN-?2, and MCP-1 could detect 92% of DHF and 79.3% of DF, specifically (P<0.01).Gal-9 appears to track DENV inflammatory responses, and therefore, it could serve as an important novel biomarker of acute DENV infection and disease severity.

SUBMITTER: Chagan-Yasutan H

PROVIDER: S-EPMC3880569 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature

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Galectin-9 plasma levels reflect adverse hematological and immunological features in acute dengue virus infection.

Chagan-Yasutan Haorile H Ndhlovu Lishomwa C LC Lacuesta Talitha Lea TL Kubo Toru T Leano Prisca Susan A PS Niki Toshiro T Oguma Shigeru S Morita Kouichi K Chew Glen M GM Barbour Jason D JD Telan Elizabeth Freda O EF Hirashima Mitsuomi M Hattori Toshio T Dimaano Efren M EM

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20131027 4

<h4>Background</h4>Dengue virus (DENV) infection remains a major public health burden worldwide. Soluble mediators may play a critical role in the pathogenesis of acute DENV infection. Galectin-9 (Gal-9) is a soluble β-galactoside-binding lectin, with multiple immunoregulatory and inflammatory properties.<h4>Objective</h4>To investigate plasma Gal-9 levels as a biomarker for DENV infection.<h4>Study design</h4>We enrolled 65 DENV infected patients during the 2010 epidemic in the Philippines and ...[more]

PMID: 24239423

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Project description:Following acute myocardial infarction, clinical studies show alterations in the blood levels of corin, a cardiac-selective activator of the natriuretic peptides pro-atrial natriuretic peptide (pro-ANP) and pro-B-type natriuretic peptide (pro-BNP). However, the temporal changes in circulating and cardiac corin levels and their relationships to the severity of myocardial infarction have not been studied. The main objective of this study was to examine the relationship between cardiac and circulating corin levels and their association with cardiac systolic function and infarct size during the early phase of acute myocardial infarction (<72 h) in a translationally relevant induced coronary ligation mouse model. This acute phase timeline was chosen to correlate with the clinical practice within which blood samples are collected from myocardial infarction patients. Heart and plasma samples were examined at 3, 24, and 72 hours post acute myocardial infarction. Plasma corin levels were examined by enzyme-linked immunosorbent assay, transcripts of cardiac corin, pro-ANP and pro-BNP by quantitative real-time polymerase chain reaction, cardiac corin expression by immunohistology, infarct size by histology and heart function by echocardiography. Plasma corin levels were significantly increased at 3 (P<0.05), 24 (P<0.001), and 72 hours (P<0.01) post-acute myocardial infarction. In contrast, cardiac corin transcript levels dropped by 5% (P>0.05), 69% (P<0.001) and 65% (P<0.001) and immunoreactive cardiac corin protein levels dropped by 30% (P<0.05), 76% (P<0.001) and 75% (P<0.001), while cardiac pro-ANP and pro-BNP transcript levels showed an opposite pattern. Plasma corin levels were negatively correlated with immunoreactive cardiac corin (P<0.01), ejection fraction (P<0.05) and fractional shortening (P<0.05), but positively correlated with infarct size (P<0.01). In conclusion, acute myocardial infarction induces rapid increases in plasma corin and decreases in cardiac corin levels. In the early phase of acute myocardial infarction, plasma corin levels are inversely correlated with heart function and may reflect the severity of myocardial damage.

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Galectin-9 plasma levels reflect adverse hematological and immunological features in acute dengue virus infection.

Publications

Galectin-9 plasma levels reflect adverse hematological and immunological features in acute dengue virus infection.

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