Ontology highlight
ABSTRACT:
SUBMITTER: Schoenfeld RC
PROVIDER: S-EPMC3880614 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Schoenfeld Ryan C RC Bourdet David L DL Brameld Ken A KA Chin Elbert E de Vicente Javier J Fung Amy A Harris Seth F SF Lee Eun K EK Le Pogam Sophie S Leveque Vincent V Li Jim J Lui Alfred S-T AS Najera Isabel I Rajyaguru Sonal S Sangi Michael M Steiner Sandra S Talamas Francisco X FX Taygerly Joshua P JP Zhao Junping J
Journal of medicinal chemistry 20131010 20
Hepatitis C virus (HCV) is a major global public health problem. While the current standard of care, a direct-acting antiviral (DAA) protease inhibitor taken in combination with pegylated interferon and ribavirin, represents a major advancement in recent years, an unmet medical need still exists for treatment modalities that improve upon both efficacy and tolerability. Toward those ends, much effort has continued to focus on the discovery of new DAAs, with the ultimate goal to provide interferon ...[more]