Ontology highlight
ABSTRACT:
SUBMITTER: Abdelkarim H
PROVIDER: S-EPMC3880688 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Abdelkarim Hazem H Brunsteiner Michael M Neelarapu Raghupathi R Bai He H Madriaga Antonett A van Breemen Richard B RB Blond Sylvie Y SY Gaponenko Vadim V Petukhov Pavel A PA
ACS chemical biology 20131002 11
Histone deacetylase 3 (HDAC3) is a promising epigenetic drug target for multiple therapeutic applications. Direct interaction between the Deacetylase Activating Domain of the silencing mediator for retinoid or thyroid-hormone receptors (SMRT-DAD) is required for activation of enzymatic activity of HDAC3. The structure of this complex and the nature of interactions with HDAC inhibitors in solution are unknown. Using novel photoreactive HDAC probes, "nanorulers", we determined the distance between ...[more]