Ontology highlight
ABSTRACT:
SUBMITTER: Aiba Y
PROVIDER: S-EPMC3880748 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Mediators of inflammation 20131221
TNF-like ligand 1A (TL1A), which binds its cognate receptor DR3 and the decoy receptor DcR3, is an identified member of the TNF superfamily. TL1A exerts pleiotropic effects on cell proliferation, activation, and differentiation of immune cells, including helper T cells and regulatory T cells. TL1A and its two receptors expression is increased in both serum and inflamed tissues in autoimmune diseases such as inflammatory bowel disease (IBD), rheumatoid arthritis (RA), and ankylosing spondylitis ( ...[more]