Ontology highlight
ABSTRACT:
SUBMITTER: Anchoori RK
PROVIDER: S-EPMC3881268 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Anchoori Ravi K RK Karanam Balasubramanyam B Peng Shiwen S Wang Joshua W JW Jiang Rosie R Tanno Toshihiko T Orlowski Robert Z RZ Matsui William W Zhao Ming M Rudek Michelle A MA Hung Chien-fu CF Chen Xiang X Walters Kylie J KJ Roden Richard B S RB
Cancer cell 20131201 6
The bis-benzylidine piperidone RA190 covalently binds to cysteine 88 of ubiquitin receptor RPN13 in the 19S regulatory particle and inhibits proteasome function, triggering rapid accumulation of polyubiquitinated proteins. Multiple myeloma (MM) lines, even those resistant to bortezomib, were sensitive to RA190 via endoplasmic reticulum stress-related apoptosis. RA190 stabilized targets of human papillomavirus (HPV) E6 oncoprotein, and preferentially killed HPV-transformed cells. After oral or in ...[more]