Ontology highlight
ABSTRACT:
SUBMITTER: Murugan M
PROVIDER: S-EPMC3881289 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Murugan Malavika M Harward Stephen S Scharff Constance C Mooney Richard R
Neuron 20131121 6
Mutations of the FOXP2 gene impair speech and language development in humans and shRNA-mediated suppression of the avian ortholog FoxP2 disrupts song learning in juvenile zebra finches. How diminished FoxP2 levels affect vocal control and alter the function of neural circuits important to learned vocalizations remains unclear. Here we show that FoxP2 knockdown in the songbird striatum disrupts developmental and social modulation of song variability. Recordings in anesthetized birds show that Fox ...[more]