Ontology highlight
ABSTRACT:
SUBMITTER: Zheng YC
PROVIDER: S-EPMC3881423 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Zheng Yi-Chao YC Duan Ying-Chao YC Ma Jin-Lian JL Xu Rui-Min RM Zi Xiaolin X Lv Wen-Lei WL Wang Meng-Meng MM Ye Xian-Wei XW Zhu Shun S Mobley David D Zhu Yan-Yan YY Wang Jun-Wei JW Li Jin-Feng JF Wang Zhi-Ru ZR Zhao Wen W Liu Hong-Min HM
Journal of medicinal chemistry 20131101 21
Lysine specific demethylase 1 (LSD1), the first identified histone demethylase, plays an important role in epigenetic regulation of gene activation and repression. The up-regulated LSD1's expression has been reported in several malignant tumors. In the current study, we designed and synthesized five series of 1,2,3-triazole-dithiocarbamate hybrids and screened their inhibitory activity toward LSD1. We found that some of these compounds, especially compound 26, exhibited the most specific and rob ...[more]