Ontology highlight
ABSTRACT:
SUBMITTER: Cardnell RJ
PROVIDER: S-EPMC3882158 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Cardnell Robert J RJ Feng Ying Y Diao Lixia L Fan You-Hong YH Masrorpour Fatemah F Wang Jing J Shen Yuqiao Y Mills Gordon B GB Minna John D JD Heymach John V JV Byers Lauren A LA
Clinical cancer research : an official journal of the American Association for Cancer Research 20130927 22
<h4>Purpose</h4>Small cell lung carcinoma (SCLC) is an aggressive malignancy affecting nearly 30,000 people annually in the United States. We have previously identified elevated PARP1 levels in SCLC and demonstrated in vitro sensitivity to the PARP inhibitors AZD 2281 and AG014699. Here, we evaluate activity of a novel, potent PARP inhibitor, BMN 673, and identify markers of response as a basis for developing predictive markers for clinical application.<h4>Experimental design</h4>Inhibition of S ...[more]