Reduced ADAMTS13 activity is associated with an ADAMTS13 SNP, fever and microparticles in a malaria-like model.
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ABSTRACT:
SUBMITTER: Kraisin S
PROVIDER: S-EPMC3882324 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Publications
Reduced ADAMTS13 activity is associated with an ADAMTS13 SNP, fever and microparticles in a malaria-like model.
Kraisin Sirima S Palasuwan Attakorn A Palasuwan Attakorn A Popruk Supaluk S Nantakomol Duangdao D
Malaria journal 20140103
<h4>Background</h4>Severe falciparum malaria (SM) remains a major cause of death in tropical countries. The reduced activity of ADAMTS13, increasing levels of ultra-large von Willebrand factor (ULVWF) in SM patients, are assumed as factors that intensify disease severity. However, the reason why ADAMTS13 activity is reduced in SM remains unclear.<h4>Objectives</h4>To investigate whether rs4962153, febrile temperature, and microparticles, contribute to reduced ADAMTS13 activity.<h4>Methods</h4>Ge ...[more]
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