Ontology highlight
ABSTRACT:
SUBMITTER: Singh RP
PROVIDER: S-EPMC3882457 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Singh Raghvendra Pratap RP Singh Raghvendra Pratap RP Blossey Ralf R Cleri Fabrizio F
Biophysical journal 20131201 12
We studied the structure and mechanical properties of DNA i-motif nanowires by means of molecular dynamics computer simulations. We built up to 230 nm-long nanowires, based on a repeated TC5 sequence from crystallographic data, fully relaxed and equilibrated in water. The unusual C⋅C(+) stacked structure, formed by four ssDNA strands arranged in an intercalated tetramer, is here fully characterized both statically and dynamically. By applying stretching, compression, and bending deformations wit ...[more]