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MicroRNA associated with dyslipidemia and coronary disease in humans.


ABSTRACT: MicroRNAs are structural components of an epigenetic mechanism of posttranscriptional regulation of messenger RNA translation. Recently, there has been significant interest in the application of microRNA as a blood-based biomarker of underlying physiological conditions. Dyslipidemia is a complex, heterogeneous condition conferring substantially increased risk for cardiovascular disease. The purpose of this review is to describe the current body of knowledge on the role of microRNA regulation of lipoprotein metabolism in humans and to discuss relevant methodological and study design considerations. We highlight the potential roles for microRNA in gene-environment interactions.

SUBMITTER: Flowers E 

PROVIDER: S-EPMC3882685 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature

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MicroRNA associated with dyslipidemia and coronary disease in humans.

Flowers Elena E   Aouizerat Bradley E BE  

Physiological genomics 20131029 24


MicroRNAs are structural components of an epigenetic mechanism of posttranscriptional regulation of messenger RNA translation. Recently, there has been significant interest in the application of microRNA as a blood-based biomarker of underlying physiological conditions. Dyslipidemia is a complex, heterogeneous condition conferring substantially increased risk for cardiovascular disease. The purpose of this review is to describe the current body of knowledge on the role of microRNA regulation of  ...[more]

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