Ontology highlight
ABSTRACT:
SUBMITTER: Germann SM
PROVIDER: S-EPMC3882784 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Germann Susanne M SM Schramke Vera V Pedersen Rune Troelsgaard RT Gallina Irene I Eckert-Boulet Nadine N Oestergaard Vibe H VH Lisby Michael M
The Journal of cell biology 20131230 1
DNA anaphase bridges are a potential source of genome instability that may lead to chromosome breakage or nondisjunction during mitosis. Two classes of anaphase bridges can be distinguished: DAPI-positive chromatin bridges and DAPI-negative ultrafine DNA bridges (UFBs). Here, we establish budding yeast Saccharomyces cerevisiae and the avian DT40 cell line as model systems for studying DNA anaphase bridges and show that TopBP1/Dpb11 plays an evolutionarily conserved role in their metabolism. Toge ...[more]