Ontology highlight
ABSTRACT:
SUBMITTER: Zambrano A
PROVIDER: S-EPMC3882795 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Zambrano Alberto A García-Carpizo Verónica V Gallardo María Esther ME Villamuera Raquel R Gómez-Ferrería Maria Ana MA Pascual Angel A Buisine Nicolas N Sachs Laurent M LM Garesse Rafael R Aranda Ana A
The Journal of cell biology 20140101 1
There is increasing evidence that the thyroid hormone (TH) receptors (THRs) can play a role in aging, cancer and degenerative diseases. In this paper, we demonstrate that binding of TH T3 (triiodothyronine) to THRB induces senescence and deoxyribonucleic acid (DNA) damage in cultured cells and in tissues of young hyperthyroid mice. T3 induces a rapid activation of ATM (ataxia telangiectasia mutated)/PRKAA (adenosine monophosphate-activated protein kinase) signal transduction and recruitment of t ...[more]