Ontology highlight
ABSTRACT:
SUBMITTER: Ciryam P
PROVIDER: S-EPMC3883113 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Ciryam Prajwal P Tartaglia Gian Gaetano GG Morimoto Richard I RI Dobson Christopher M CM Vendruscolo Michele M
Cell reports 20131031 3
The maintenance of protein solubility is a fundamental aspect of cellular homeostasis because protein aggregation is associated with a wide variety of human diseases. Numerous proteins unrelated in sequence and structure, however, can misfold and aggregate, and widespread aggregation can occur in living systems under stress or aging. A crucial question in this context is why only certain proteins appear to aggregate readily in vivo, whereas others do not. We identify here the proteins most vulne ...[more]