Association of the IFNL4-?G Allele With Impaired Spontaneous Clearance of Hepatitis C Virus.

ABSTRACT: Interferon lambda 4 protein can be generated in IFNL4-?G carriers but not IFNL4-TT homozygotes. We studied 890 anti-hepatitis C virus (HCV)-positive participants in the Women's Interagency HIV Study. Among blacks (n = 555), HCV was more often cleared for those with genotype IFNL4-TT/TT (32.6%; odds ratio [OR], 3.59; P = 3.3 × 10(-5)) than IFNL4-TT/?G (11.3%; OR, 0.95; P = .86) or IFNL4-?G/?G (11.9%; referent). Pooling these data with published results in blacks (n = 1678), ORs were 3.84 (P = 8.6 × 10(-14)) for IFNL4-TT/TT and 1.44 (P = .03) IFNL4-TT/?G, and the area under the curve was 0.64 for IFNL4-?G genotype and 0.61 for rs12979860 (IL28B). IFNL4-?G is strongly associated with impaired spontaneous HCV clearance.

SUBMITTER: Aka PV 

PROVIDER: S-EPMC3883162 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature