Dataset Information

Salivary inflammatory mediator profiling and correlation to clinical disease markers in asthma.

ABSTRACT:

Rationale

There is a need for a readily available, non-invasive source of biomarkers that predict poor asthma control.

Objectives

We sought to determine if there is an association between the salivary inflammatory profile and disease control in children and adults with asthma.

Methods

In this cross-sectional study, we collected demographic and clinical information from two independent populations at different sites, resulting in convenience samples of 58 pediatric and 122 adult urban asthmatics. Control was assessed by symptom questionnaire (children) and by Asthma Control Questionnaire and current exacerbation (adults). Saliva was collected in all subjects. We applied principal component analysis to a 10-plex panel of relevant inflammatory markers to characterize marker profiles and determined if profiles were associated with asthma control.

Results

There were similar, strong correlations amongst biologically related markers in both populations: eosinophil-related: eotaxin-1/CCL11, RANTES/CCL5, and IL-5 (p<.001); myeloid/innate: IL-1?, IL-6, MCP-1/CCL2, and IL-8/CXCL8 (p<.001). The first three principal components captured ?74% of variability across all ten analytes in both populations. In adults, the Principal Component 1 score, broadly reflective of all markers, but with greater weight given to myeloid/innate markers, was associated with Asthma Control Questionnaire score and exacerbation. The Principal Component 3 score, reflective of IP-10/CXCL10, was associated with current exacerbation. In children, the Principal Component 1, 2, and 3 scores were associated with recent asthma symptoms. The Principal Component 2 score, reflective of higher eosinophil markers, was inversely correlated with symptoms. The Principal Component 3 score was positively associated with all symptom outcomes.

Conclusion

The salivary inflammatory profile is associated with disease control in children and adults with asthma.

SUBMITTER: Little FF

PROVIDER: S-EPMC3883659 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Publications

Salivary inflammatory mediator profiling and correlation to clinical disease markers in asthma.

Little Frédéric F FF Delgado Diana M DM Wexler Philip J PJ Oppenheim Frank G FG Mitchell Patricia P Feldman James A JA Walt David R DR Peng Roger D RD Matsui Elizabeth C EC

PloS one 20140107 1

<h4>Rationale</h4>There is a need for a readily available, non-invasive source of biomarkers that predict poor asthma control.<h4>Objectives</h4>We sought to determine if there is an association between the salivary inflammatory profile and disease control in children and adults with asthma.<h4>Methods</h4>In this cross-sectional study, we collected demographic and clinical information from two independent populations at different sites, resulting in convenience samples of 58 pediatric and 122 a ...[more]

PMID: 24409298

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Dataset Information

Salivary inflammatory mediator profiling and correlation to clinical disease markers in asthma.

Rationale

Objectives

Methods

Results

Conclusion

Publications

Salivary inflammatory mediator profiling and correlation to clinical disease markers in asthma.

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