Ontology highlight
ABSTRACT:
SUBMITTER: Robinson SN
PROVIDER: S-EPMC3883688 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Robinson Simon N SN Thomas Michael W MW Simmons Paul J PJ Lu Junjun J Yang Hong H Parmar Simrit S Liu Xiaoying X Shah Nina N Martín-Antonio Beatriz B Bollard Catherine C Dotti Gianpietro G Savoldo Barbara B Cooper Laurence J LJ Najjar Amer A Rezvani Katayoun K Kaur Indreshpaul I McNiece Ian K IK Champlin Richard E RE Miller Leonard P LP Zweidler-McKay Patrick A PA Shpall Elizabeth J EJ
Cytotherapy 20131001 1
<h4>Background aims</h4>Advantages associated with the use of cord blood (CB) transplantation include the availability of cryopreserved units, ethnic diversity and lower incidence of graft-versus-host disease compared with bone marrow or mobilized peripheral blood. However, poor engraftment remains a major obstacle. We and others have found that ex vivo fucosylation can enhance engraftment in murine models, and now ex vivo treatment of CB with fucosyltransferase (FT) VI before transplantation is ...[more]