Ontology highlight
ABSTRACT:
SUBMITTER: Luo S
PROVIDER: S-EPMC3884581 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Luo Sheng S Ma Junsheng J Kieburtz Karl D KD
Statistics in medicine 20130311 22
Many randomized clinical trials collect multivariate longitudinal measurements in different scales, for example, binary, ordinal, and continuous. Multilevel item response models are used to evaluate the global treatment effects across multiple outcomes while accounting for all sources of correlation. Continuous measurements are often assumed to be normally distributed. But the model inference is not robust when the normality assumption is violated because of heavy tails and outliers. In this art ...[more]