Ontology highlight
ABSTRACT:
SUBMITTER: Cottrell EC
PROVIDER: S-EPMC3884597 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Cottrell Elizabeth C EC Martin-Gronert Malgorzata S MS Fernandez-Twinn Denise S DS Luan Jian'an J Berends Lindsey M LM Ozanne Susan E SE
Endocrinology 20110105 2
Low birth weight and rapid postnatal weight gain are independent and additive risk factors for the subsequent development of metabolic disease. Despite an abundance of evidence for these associations, mechanistic data are lacking. The hormone leptin has received significant interest as a potential programming factor, because differences in the profile of leptin in early life have been associated with altered susceptibility to obesity. Whether leptin alone is a critical factor for programming obe ...[more]