Ontology highlight
ABSTRACT:
SUBMITTER: Schlackow M
PROVIDER: S-EPMC3884648 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Schlackow Margarita M Marguerat Samuel S Proudfoot Nicholas J NJ Bähler Jürg J Erban Radek R Gullerova Monika M
RNA (New York, N.Y.) 20131023 12
Polyadenylation of pre-mRNAs, a critical step in eukaryotic gene expression, is mediated by cis elements collectively called the polyadenylation signal. Genome-wide analysis of such polyadenylation signals was missing in fission yeast, even though it is an important model organism. We demonstrate that the canonical AATAAA motif is the most frequent and functional polyadenylation signal in Schizosaccharomyces pombe. Using analysis of RNA-Seq data sets from cells grown under various physiological ...[more]