Ontology highlight
ABSTRACT:
SUBMITTER: Russell RC
PROVIDER: S-EPMC3885611 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Russell Ryan C RC Tian Ye Y Yuan Haixin H Park Hyun Woo HW Chang Yu-Yun YY Kim Joungmok J Kim Haerin H Neufeld Thomas P TP Dillin Andrew A Guan Kun-Liang KL
Nature cell biology 20130519 7
Autophagy is the primary cellular catabolic program activated in response to nutrient starvation. Initiation of autophagy, particularly by amino-acid withdrawal, requires the ULK kinases. Despite its pivotal role in autophagy initiation, little is known about the mechanisms by which ULK promotes autophagy. Here we describe a molecular mechanism linking ULK to the pro-autophagic lipid kinase VPS34. Following amino-acid starvation or mTOR inhibition, the activated ULK1 phosphorylates Beclin-1 on S ...[more]