Unknown

Dataset Information

0

IL-15 deficient tax mice reveal a role for IL-1? in tumor immunity.


ABSTRACT: IL-15 is recognized as a promising candidate for tumor immunotherapy and has been described as both a promoter of cancer and a promoter of anti-cancer immunity. IL-15 was discovered in cells transformed by HTLV-1, the etiologic agent of adult T cell leukemia/lymphoma (ATL) and the human retrovirus that carries the Tax oncogene. We have developed the TAX-LUC mouse model of ATL in which Tax expression drives both malignant transformation and luciferase expression, enabling non-invasive imaging of tumorigenesis in real time. To identify the role of IL-15 in spontaneous development of lymphoma in vivo, an IL-15(-/-) TAX-LUC strain was developed and examined. The absence of IL-15 resulted in aggressive tumor growth and accelerated mortality and demonstrated that IL-15 was not required for Tax-mediated lymphoma but was essential for anti-tumor immunity. Further analysis revealed a unique transcriptional profile in tumor cells that arise in the absence of IL-15 that included a significant increase in the expression of IL-1? and IL-1?-regulated cytokines. Moreover, anti-IL-1? antibodies and an IL-1 receptor antagonist (Anakinra) were used to interrogate the potential of IL-1? targeted therapies in this model. Taken together, these findings identify IL-15 and IL-1? as therapeutic targets in lymphoma.

SUBMITTER: Rauch DA 

PROVIDER: S-EPMC3885672 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

altmetric image

Publications

IL-15 deficient tax mice reveal a role for IL-1α in tumor immunity.

Rauch Daniel A DA   Harding John C JC   Ratner Lee L  

PloS one 20140108 1


IL-15 is recognized as a promising candidate for tumor immunotherapy and has been described as both a promoter of cancer and a promoter of anti-cancer immunity. IL-15 was discovered in cells transformed by HTLV-1, the etiologic agent of adult T cell leukemia/lymphoma (ATL) and the human retrovirus that carries the Tax oncogene. We have developed the TAX-LUC mouse model of ATL in which Tax expression drives both malignant transformation and luciferase expression, enabling non-invasive imaging of  ...[more]

Similar Datasets

2013-06-11 | GSE46072 | GEO
2013-06-11 | E-GEOD-46072 | biostudies-arrayexpress
| S-EPMC5407912 | biostudies-literature
| S-EPMC9280705 | biostudies-literature
| S-EPMC2791057 | biostudies-literature
| S-EPMC3596415 | biostudies-literature
2022-05-11 | GSE176311 | GEO
| S-EPMC4570106 | biostudies-literature
| S-EPMC7526542 | biostudies-literature
| S-EPMC3087530 | biostudies-literature