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Fatal Cryptococcus gattii genotype AFLP5 infection in an immunocompetent Cuban patient.

ABSTRACT: We describe the first clinical case of cryptococcosis due C. gattii in a Cuban immunocompetent patient who had a traveling history two years before to Central America. Molecular characterization of the isolate showed it to be genotype AFLP5 of which MLST sequences clustered with clinical and environmental strains from Colombia. The patient died one year after the diagnosis despite a prolonged treatment with (liposomal) amphotericin B, fluconazole, voriconazole and gamma interferon.

SUBMITTER: Illnait-Zaragozi MT

PROVIDER: S-EPMC3885943 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature

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Fatal Cryptococcus gattii genotype AFLP5 infection in an immunocompetent Cuban patient.

Illnait-Zaragozí María T MT Ortega-Gonzalez Lilia M LM Hagen Ferry F Martínez-Machin Gerardo F GF Meis Jacques F JF

Medical mycology case reports 20130209

We describe the first clinical case of cryptococcosis due C. gattii in a Cuban immunocompetent patient who had a traveling history two years before to Central America. Molecular characterization of the isolate showed it to be genotype AFLP5 of which MLST sequences clustered with clinical and environmental strains from Colombia. The patient died one year after the diagnosis despite a prolonged treatment with (liposomal) amphotericin B, fluconazole, voriconazole and gamma interferon. ...[more]

PMID: 24432215

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