Ontology highlight
ABSTRACT:
SUBMITTER: Rodrigues TB
PROVIDER: S-EPMC3886895 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Rodrigues Tiago B TB Serrao Eva M EM Kennedy Brett W C BW Hu De-En DE Kettunen Mikko I MI Brindle Kevin M KM
Nature medicine 20131208 1
In this study, we monitored glycolysis in mouse lymphoma and lung tumors by measuring the conversion of hyperpolarized [U-2H, U-13C]glucose to lactate using 13C magnetic resonance spectroscopy and spectroscopic imaging. We observed labeled lactate only in tumors and not in surrounding normal tissue or other tissues in the body and found that it was markedly decreased at 24 h after treatment with a chemotherapeutic drug. We also detected an increase in a resonance assigned to 6-phosphogluconate i ...[more]