Trends in the association of parental history of obesity over 60 years.
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ABSTRACT:
SUBMITTER: Fox CS
PROVIDER: S-EPMC3887126 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Publications
Trends in the association of parental history of obesity over 60 years.
Fox Caroline S CS Pencina Michael J MJ Heard-Costa Nancy L NL Shrader Peter P Jaquish Cashell C O'Donnell Christopher J CJ Vasan Ramachandran S RS Cupples L Adrienne LA D'Agostino Ralph B RB
Obesity (Silver Spring, Md.) 20140206 3
<h4>Objective</h4>The association of familial as compared to genetic factors in the current obesogenic environment, compared with earlier, leaner time periods, is uncertain.<h4>Methods</h4>Participants from the Framingham Heart Study were classified according to parental obesity status in the Original, Offspring, and Third Generation cohorts; mean BMI levels were estimated and we compared the association of parental history across generations. Finally, a genetic risk score comprised of 32 well-r ...[more]
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