Dataset Information

Trends in the association of parental history of obesity over 60 years.

ABSTRACT:

Objective

The association of familial as compared to genetic factors in the current obesogenic environment, compared with earlier, leaner time periods, is uncertain.

Methods

Participants from the Framingham Heart Study were classified according to parental obesity status in the Original, Offspring, and Third Generation cohorts; mean BMI levels were estimated and we compared the association of parental history across generations. Finally, a genetic risk score comprised of 32 well-replicated single nucleotide polymorphisms for BMI was examined in association with BMI levels in 1948, 1971, and 2002.

Results

BMI was 1.49 kg/m2 higher per each affected parent among the Offspring, and increased to 2.09 kg/m2 higher among the Third Generation participants (P-value for the cohort comparison=0.007). Parental history of obesity was associated with increased weight gain (P < 0.0001) and incident obesity (P = 0.009). Despite a stronger association of parental obesity with offspring BMI in more contemporary time periods, we observed no change in the effect size of a BMI genetic risk score from 1948 to 2002 (P = 0.11 for test of trend across the time periods).

Conclusions

The association of parental obesity has become stronger in more contemporary time period, whereas the association of a BMI genetic risk score has not changed.

SUBMITTER: Fox CS

PROVIDER: S-EPMC3887126 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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Publications

Trends in the association of parental history of obesity over 60 years.

Fox Caroline S CS Pencina Michael J MJ Heard-Costa Nancy L NL Shrader Peter P Jaquish Cashell C O'Donnell Christopher J CJ Vasan Ramachandran S RS Cupples L Adrienne LA D'Agostino Ralph B RB

Obesity (Silver Spring, Md.) 20140206 3

<h4>Objective</h4>The association of familial as compared to genetic factors in the current obesogenic environment, compared with earlier, leaner time periods, is uncertain.<h4>Methods</h4>Participants from the Framingham Heart Study were classified according to parental obesity status in the Original, Offspring, and Third Generation cohorts; mean BMI levels were estimated and we compared the association of parental history across generations. Finally, a genetic risk score comprised of 32 well-r ...[more]

PMID: 23836774

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Dataset Information

Trends in the association of parental history of obesity over 60 years.

Objective

Methods

Results

Conclusions

Publications

Trends in the association of parental history of obesity over 60 years.

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