Ontology highlight
ABSTRACT:
SUBMITTER: Cole DK
PROVIDER: S-EPMC3887192 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Cole David K DK Miles Kim M KM Madura Florian F Holland Christopher J CJ Schauenburg Andrea J A AJ Godkin Andrew J AJ Bulek Anna M AM Fuller Anna A Akpovwa Hephzibah J E HJ Pymm Phillip G PG Liddy Nathaniel N Sami Malkit M Li Yi Y Rizkallah Pierre J PJ Jakobsen Bent K BK Sewell Andrew K AK
The Journal of biological chemistry 20131106 2
αβ T-cell receptors (TCRs) engage antigens using complementarity-determining region (CDR) loops that are either germ line-encoded (CDR1 and CDR2) or somatically rearranged (CDR3). TCR ligands compose a presentation platform (major histocompatibility complex (MHC)) and a variable antigenic component consisting of a short "foreign" peptide. The sequence of events when the TCR engages its peptide-MHC (pMHC) ligand remains unclear. Some studies suggest that the germ line elements of the TCR engage t ...[more]