Ontology highlight
ABSTRACT:
SUBMITTER: Dalmasso AP
PROVIDER: S-EPMC3887209 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Dalmasso Agustin P AP Goldish Daniel D Benson Barbara A BA Tsai Alexander K AK Wasiluk Karen R KR Vercellotti Gregory M GM
The Journal of biological chemistry 20131126 2
Injury to endothelial cells (ECs) often results in cell retraction and gap formation. When caused by antigen aggregation or complement, this injury can be prevented by pretreatment of the ECs with IL-4, suggesting that IL-4 modifies the intercellular junction. Therefore, we investigated the effects of IL-4 on expression of intercellular junction proteins and whether such effects are required for IL-4-induced resistance of ECs against complement-mediated injury. We found that IL-4 induces upregul ...[more]