Ontology highlight
ABSTRACT:
SUBMITTER: Subramanian K
PROVIDER: S-EPMC3887452 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Subramanian Kartik K Owens Derek Jason DJ Raju Ravali R Firpo Meri M O'Brien Timothy D TD Verfaillie Catherine M CM Hu Wei-Shou WS
Stem cells and development 20131022 2
Stem cell-derived hepatocyte-like cells hold great potential for the treatment of liver disease and for drug toxicity screening. The success of these applications hinges on the generation of differentiated cells with high liver specific activities. Many protocols have been developed to guide human embryonic stem cells (hESCs) to differentiate to the hepatic lineage. Here we report cultivation of hESCs as three-dimensional aggregates that enhances their differentiation to hepatocyte-like cells. D ...[more]