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ABSTRACT: Objective
The interleukin 2 (IL-2) and interleukin 21 (IL-21) locus at chromosome 4q27 has been associated with several autoimmune diseases, and both genes are related to immune system functions. The aim of this study was to evaluate the role of the IL-2/IL-21 locus in systemic sclerosis (SSc).Patients and methods
The case control study included 4493 SSc Caucasian patients and 5856 healthy controls from eight Caucasian populations (Spain, Germany, The Netherlands, USA, Italy, Sweden, UK and Norway). Four single nucleotide polymorphisms (rs2069762, rs6822844, rs6835457 and rs907715) were genotyped using TaqMan allelic discrimination assays.Results
We observed evidence of association of the rs6822844 and rs907715 variants with global SSc (pc=6.6E-4 and pc=7.2E-3, respectively). Similar statistically significant associations were observed for the limited cutaneous form of the disease. The conditional regression analysis suggested that the most likely genetic variation responsible for the association was the rs6822844 polymorphism. Consistently, the rs2069762A-rs6822844T-rs6835457G-rs907715T allelic combination showed evidence of association with SSc and limited cutaneous SSc subtype (pc=1.7E-03 and pc=8E-4, respectively).Conclusions
These results suggested that the IL-2/IL-21 locus influences the genetic susceptibility to SSc. Moreover, this study provided further support for the IL-2/IL-21 locus as a common genetic factor in autoimmune diseases.
SUBMITTER: Diaz-Gallo LM
PROVIDER: S-EPMC3887514 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Diaz-Gallo Lina-Marcela LM Simeon Carmen P CP Broen Jasper C JC Ortego-Centeno Norberto N Beretta Lorenzo L Vonk Madelon C MC Carreira Patricia E PE Vargas Sofia S Román-Ivorra José Andrés JA González-Gay Miguel A MA Tolosa Carlos C López-Longo Francisco Javier FJ Espinosa Gerard G Vicente Esther F EF Hesselstrand Roger R Riemekasten Gabriela G Witte Torsten T Distler Jörg H W JH Voskuyl Alexandre E AE Schuerwegh Annemie J AJ Shiels Paul G PG Nordin Annika A Padyukov Leonid L Hoffmann-Vold Anna-Maria AM Scorza Raffaella R Lunardi Claudio C Airo Paolo P van Laar Jacob M JM Hunzelmann Nicolas N Gathof Birgit S BS Kreuter Alexander A Herrick Ariane A Worthington Jane J Denton Christopher P CP Zhou Xiaodong X Arnett Frank C FC Fonseca Carmen C Koeleman Bobby P C BP Assasi Shervin S Radstake Timothy R D J TR Mayes Maureen D MD Martín Javier J
Annals of the rheumatic diseases 20121121 7
<h4>Objective</h4>The interleukin 2 (IL-2) and interleukin 21 (IL-21) locus at chromosome 4q27 has been associated with several autoimmune diseases, and both genes are related to immune system functions. The aim of this study was to evaluate the role of the IL-2/IL-21 locus in systemic sclerosis (SSc).<h4>Patients and methods</h4>The case control study included 4493 SSc Caucasian patients and 5856 healthy controls from eight Caucasian populations (Spain, Germany, The Netherlands, USA, Italy, Swe ...[more]